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Test Prep

Test Tips for PMHNP Boards

Common SUD Screening Tools

Common SUD Screening Tools

Common SUD Screening Tools

Screening tools are used often in SUD treatment. Some are specific for specific substances.  The screening tools are different for CIWA and COWS as those address in particular the withdrawal symptoms  while monitoring patients going through SUD treatment. 

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Alcohol Withdrawal & CIWA

Common SUD Screening Tools

Common SUD Screening Tools

The Clinical Institute Withdrawal Assessment for Alcohol, Revised (CIWA-Ar) scale is a comprehensive, standardized tool widely used in clinical settings to assess the severity of alcohol withdrawal symptoms. Developed to facilitate a safe and effective management of alcohol withdrawal.

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Nicotine Use & Teens

Common SUD Screening Tools

Nicotine Use & Teens

With teens, it can be a little tricky. Merely telling/educating them about the risk alone may not be effective. Your technique may have to involve strategies from Motivational Interviewing.  It's essential to frame questions in a way that encourages reflection, personal insight, and the development of intrinsic motivation to avoid smoking. 

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Antipsychotic & Stimulants Simultaneously?

Antipsychotic & Stimulants Simultaneously?

Antipsychotic & Stimulants Simultaneously?

 Most of the anecdotal data regarding stimulant and antipsychotic use comes from treatment of pediatric population – children treated with LONG-TERM regimen of  amphetamines/ psychostimulants in whom psychosis has been reported. Most of the scientific community focuses on this as a caution, EVEN THOUGH other studies have shown that concomitant use of antipsychotics and psychostimulants can be safe and effective especially in adults.

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Clozapine induced Sialorrhea

Antipsychotic & Stimulants Simultaneously?

Antipsychotic & Stimulants Simultaneously?

High % of patients taking Clozapine experience sialorrhea. Thought to be either due to Clozapine's stimulation of M4 muscarinic and blockade of Alpha 2 receptors OR it could be related to decreased laryngeal peristalsis. How to treat?


Other side effects of Clozapine besides sialorrhea include agranulocytosis, myocarditis, seizures, etc.

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Serotonin Syndrome - Combining MAOIs?

Antipsychotic & Stimulants Simultaneously?

Serotonin Syndrome - Combining MAOIs?

The important starting point is to understand the mechanism of Serotonin formation and action. Serotonin is made from amino acid tryptophan and stored in presynaptic terminal. Through the activation of the neuron/action potentials, it gets released into the synapse and had an impact on pre and post synaptic neuron before getting reabsorbed into the presynaptic terminal only to be degraded by MONOAMINE (SE, DA, NE) OXIDASE (enzyme that breaks the monoamines).   

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Rapid Cycling & Medical Diagnosis

Hypoglycemia Awareness in Child & Adolescent Psychiatry

Rapid Cycling & Medical Diagnosis

 Mental health conditions are often influenced by underlying medical conditions, and understanding these connections is essential for accurate diagnosis and effective treatment. One such concern is rapid cycling, a pattern of mood episodes that can significantly impact an individual’s emotional and physical well-being. While rapid cycling is commonly associated with bipolar disorder, it can also be triggered or exacerbated by underlying medical conditions that affect hormone regulation, metabolism, or neurological function.

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Least Sedating AUD Medication

Hypoglycemia Awareness in Child & Adolescent Psychiatry

Rapid Cycling & Medical Diagnosis

 

Alcohol Use Disorder (AUD) is a chronic condition that affects millions of people worldwide, leading to severe health, social, and psychological consequences. While behavioral therapy and support groups like Alcoholics Anonymous (AA) are valuable treatment options, medications can also play a crucial role in reducing cravings, preventing relapse, and supporting long-term recovery.

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Hypoglycemia Awareness in Child & Adolescent Psychiatry

Hypoglycemia Awareness in Child & Adolescent Psychiatry

Hypoglycemia Awareness in Child & Adolescent Psychiatry

 Child and adolescent psychiatry often focuses on behavioral, emotional, and developmental issues, but it is critical not to overlook the role of physical health conditions—like hypoglycemia—that can present with symptoms mimicking psychiatric disorders. 


Hypoglycemia awareness in children and adolescents with Type 1 Diabetes Mellitus (T1DM) or other metabolic conditions is essential for comprehensive mental health care.  

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Impulsivity & Brain Anatomy

Statins & Depression -Possible Mechanisms

Impulsivity & Brain Anatomy

 When a patient becomes more impulsive, the primary brain region involved is the frontal lobe, specifically the prefrontal cortex (PFC), particularly the orbitofrontal cortex (OFC) and ventromedial prefrontal cortex (vmPFC). These areas are responsible for impulse control, decision-making, and emotional regulation. 

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Pregnancy & SUD Treatments

Statins & Depression -Possible Mechanisms

Impulsivity & Brain Anatomy

Medication choices in pregnancy:

--Substance Use Disorder:

Alcohol

Opioid 

Stimulant

Sedative 

Nicotine 


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Statins & Depression -Possible Mechanisms

Statins & Depression -Possible Mechanisms

Statins & Depression -Possible Mechanisms

The relationship between statins and depression is an area of ongoing research, and the potential mechanisms are still being explored. Here are some possible mechanisms by which statins could be linked to depression: 

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Tamoxifen & Depression - Possible Mechanisms

Interferon & Depression - Possible Mechanisms

Interferon & Depression - Possible Mechanisms

Tamoxifen, commonly used in the treatment of hormone receptor-positive breast cancer, has been associated with depression in some patients. The mechanisms behind this association are not fully understood, but several theories suggest how tamoxifen might influence mood: 

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Interferon & Depression - Possible Mechanisms

Interferon & Depression - Possible Mechanisms

Interferon & Depression - Possible Mechanisms

Interferon, a medication widely used in the treatment of certain viral infections and some types of cancer, is known to be associated with the development of depression in some patients. The mechanisms underlying this association are complex and involve several biological pathways: 


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Fluoxetine & St. John's Wort together?

Interferon & Depression - Possible Mechanisms

Fluoxetine & St. John's Wort together?

Can they be taken simultaneously?

What happens with the P450 Enzyme Activity?


-- CYP3A4

-- CYP2C19 and CYP2C9 

-- P-glycoprotein 

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CAGE Questionnaire & AUD

Steroids - Inducers or Inhibitors

Steroids - Inducers or Inhibitors

The CAGE questionnaire is a brief screening tool used to assess the presence of problematic alcohol use and potential alcohol use disorder (AUD). It consists of four simple questions, each corresponding to a letter in the acronym "CAGE." The CAGE questionnaire is widely used in clinical settings due to its simplicity and effectiveness in identifying individuals who may have alcohol-related issues. While originally designed for alcohol use, it has also been adapted for screening other substance use disorders (SUDs). 

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Steroids - Inducers or Inhibitors

Steroids - Inducers or Inhibitors

Steroids - Inducers or Inhibitors

 The classification of some steroids as inducers and others as inhibitors of psychiatric medications is primarily a result of their interaction with the cytochrome P450 (CYP450) enzyme system in the liver, which is responsible for the metabolism of many drugs, including psychiatric medications. The specific effect of a steroid on this enzyme system depends on its chemical structure and how it interacts with the enzymes. 


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Is Atorvastatin an Inducer?

Steroids - Inducers or Inhibitors

Is Atorvastatin an Inducer?

Atorvastatin (Lipitor) is not typically classified as an inducer of psychotropic medications per say. Drug inducers are substances that increase the metabolic activity of enzymes, leading to decreased plasma concentration and reduced efficacy of other medications.


Lipitor works mainly by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis. Its interaction with psychotropic medications, if any, is more likely to be due to competition for the same metabolic pathways (especially liver enzymes like CYP450 isoforms) rather than induction.

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Gastric Motility & Anorexia

Prioritization of Actions - Medication Toxicity

Prioritization of Actions - Medication Toxicity

Erythromycin and Metoclopramide/Reglan are two medications that can increase gastric motility, and they have been explored for use in patients with conditions like gastroparesis or delayed gastric emptying, which can sometimes be a concern in patients with anorexia. Their mechanisms of action, while aimed at enhancing gastrointestinal motility, are not the same. 

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Prioritization of Actions - Medication Toxicity

Prioritization of Actions - Medication Toxicity

Prioritization of Actions - Medication Toxicity

I've had questions about this in the past, so will clarify further in a separate post. Most questions will not include ABCs or stability type questions on the board exams. There may be 1-2 questions that may have you prioritize as such. Look for what is included in the question. Does the question specify that assessments have been completed already in the ED or you are the one responding to the patient first? 

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Derailment & Tangential Thinking

Prioritization of Actions - Medication Toxicity

Derailment & Tangential Thinking

Derailment and tangential thinking are both types of disorganized speech, often observed in psychiatric conditions such as schizophrenia, bipolar disorder during manic phases, or other mental health disorders affecting thought processes. Despite their similarities, they have distinct characteristics: 

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Dementia & Frontal Love

CRAFFT - SUD Screening for Adolescents

Dementia & Frontal Love

Dementia can affect various parts of the brain, but changes in the frontal lobe are particularly significant, especially in certain types of dementia like frontotemporal dementia (FTD). The frontal lobes are crucial for cognitive functions such as problem-solving, planning, impulse control, and judgment, as well as emotional expression. When dementia affects the frontal lobe, the following changes and symptoms can occur: 

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Negative Landau Test

CRAFFT - SUD Screening for Adolescents

Dementia & Frontal Love

The Landau reflex, often explored through the Landau test, is a primitive reflex seen in infants and is considered an important indicator of neurodevelopmental progress. This reflex is typically observed between the ages of 3 months and 2 years. The test not only assesses the integrity of the baby's motor development but also provides insight into the central nervous system's maturity. Understanding the Landau reflex involves examining how it is performed, its normal developmental timeline, and the implications of both positive and negative findings. 

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CRAFFT - SUD Screening for Adolescents

CRAFFT - SUD Screening for Adolescents

CRAFFT - SUD Screening for Adolescents

The CRAFFT tool is a validated and reliable screening tool used in clinical practice to identify substance use disorders among adolescents (12-21 years). Its structured format and ease of administration make it a valuable tool for healthcare professionals working with young people. It is an acronym representing key questions related to substance use and risk behaviors. Here's an extensive breakdown of the CRAFFT tool: 

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Diabetic Ketoacidosis and Kussmaul Respirations

Diabetic Ketoacidosis and Kussmaul Respirations

Diabetic Ketoacidosis and Kussmaul Respirations

Kussmaul respirations are a type of hyperventilation or deep, labored breathing pattern associated with diabetic ketoacidosis. Kussmaul respirations are a hallmark sign of severe metabolic acidosis, particularly in DKA, indicating the body's effort to correct the acidic blood pH through increased respiration and CO2 elimination. This compensatory mechanism is an important clinical sign and helps guide the diagnosis and management of patients with DKA. 

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SUD & Dopamine & Mesolimbic

Diabetic Ketoacidosis and Kussmaul Respirations

Diabetic Ketoacidosis and Kussmaul Respirations

Substance Use Disorder (SUD) involves a complex interplay of various neurotransmitters and neural pathways, underpinning the compulsive use of substances despite harmful consequences. Understanding the role of neurotransmitters and the pathways implicated in addiction is crucial for developing effective treatments. Here's an organized overview: 

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SUD & FRAMES Model

Diabetic Ketoacidosis and Kussmaul Respirations

SUD & FRAMES Model

The FRAMES model is an evidence-based approach for conducting brief interventions with individuals experiencing substance use issues. It is designed to be flexible, allowing for adaptation to different settings and populations. The acronym FRAMES stands for Feedback, Responsibility, Advice, Menu of Options, Empathic Style, and Self-efficacy. 

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